I think it has gone on strike! Help required

Need some help. I was just out driving, cruising in 5th at about 50mph, go to accelerate a little and it splutters a little (a bit like the kangerooing they do) dropped it down a gear or 2 and it was the same. It seems OK when cruising at a constant speed, however when trying to accelerate it seems like it is misfiring, it is the same on idle. I disconnected the coil packs in turn, going from the cambelt side, cylinder 1 it almost cut out, 2 and 3 revs dropped a little, 4 was somewhere in between. Any ideas/pointers? Clio 197 btw